Transfer RNA and human disease
نویسندگان
چکیده
منابع مشابه
Transfer RNA and human disease
Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are "hotspots" for pathological mutations and over 200 mt-tRNA mutations have been linked to various disease states. Often these mutations prevent tRNA aminoacylation. Disrupting this primary function affects protein synthesis and t...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2014
ISSN: 1664-8021
DOI: 10.3389/fgene.2014.00158